Oncology-related literature
Publications
Selected publications
Representative peer‑reviewed articles, reviews and open‑access papers relevant to the laboratory's focus (thymoquinone, DNA damage signalling, Chk1, DNA‑PK, radiosensitization and p53 biology).
International Journal of Oncology
Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53‑dependent mechanism.
Cellular and Molecular Life Sciences / Open access (PMC)
Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models.
Chemico‑Biological Interactions
Redox cycling of endogenous copper by thymoquinone leads to ROS‑mediated DNA breakage and consequent cell death.
↗
International Journal of Radiation Biology
DNA‑PK: the major target for wortmannin‑mediated radiosensitization by the inhibition of DSB repair via NHEJ pathway.
Science / oncology literature
Targeted radiosensitization by Chk1 inhibitors: preclinical evidence for selective sensitization of p53‑defective cells.
Biochemical and Biophysical Research Communications
Human DNA‑activated protein kinase phosphorylates serines 15 and 37 in p53.
Various reviews